FIG 1.

(A) Chemical structure of “reversed chloroquine” (RCQ) compounds PL69 (compound 22 in reference 11) and PL106. (B) Ex vivo drug susceptibility (median IC₅₀s) to standard antimalarials and the RCQ compounds PL69 and PL106 in P. falciparum (closed symbols) and P. vivax (open symbols) clinical isolates. Significance of P values was determined by Wilcoxon rank sum test. (C and D) Ex vivo drug susceptibilities (median IC₅₀s) for PL69 (C) and PL106 (D) according to species tested and for paired ring-stage (closed symbols) versus trophozoite-stage (open symbols) parasites. Significance of P values was determined by Wilcoxon rank sum test.