FIG 5.

Protective effect of Rg1 and Re on LPS-induced lethality in mice. (A and B) Preventive effect of Rg1 (A) and Re (B). Mice were randomly allocated into 7 groups (n = 10) and were subcutaneously injected with various doses of Rg1 (A) or Re (B), TAK-242, or saline solution 3 times at 30-min intervals as indicated in the figure legends. Fifteen minutes after the last injection, mice were challenged with LPS (i.p.), except for the mice in the control group, which received saline solution only. (C) Therapeutic effects of Rg1 and Re. Mice were randomly allocated into 5 groups (n = 10) and left untreated or injected with LPS (20 mg/kg, i.p.). After 15 min, mice were subcutaneously administered Rg1 (10 mg/kg), Re (20 mg/kg), TAK-242 (5 mg/kg), or saline solution three times at 30-min intervals. Survival data were analyzed using the log-rank test.