TABLE 4.
Nonsusceptible rates of most common serogroups/types observed among noninvasive S. pneumoniae isolates collected during 2009 to 2012 in the United States
| Serogroup/type | % nonsusceptibilitya by yr |
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Penicillin |
Ceftriaxone |
Clindamycin |
Erythromycin |
|||||||||||||
| 2009 | 2010 | 2011 | 2012 | 2009 | 2010 | 2011 | 2012 | 2009 | 2010 | 2011 | 2012 | 2009 | 2010 | 2011 | 2012 | |
| PCV7 | 32.0 (52.0) | 28.9 (52.6) | 19.1 (55.3) | 16.2 (51.4) | 28.0 | 21.1 | 17.0 | 21.6 | 32.0 | 31.6 | 23.4 | 18.9 | 52.0 | 52.6 | 59.6 | 48.6 |
| 19F | 26.7 (46.7) | 33.3 (50.0) | 25.8 (45.2) | 20.0 (60.0) | 20.0 | 25.0 | 22.6 | 20.0 | 40.0 | 37.5 | 29.0 | 24.0 | 46.7 | 50.0 | 41.9 | 40.0 |
| Additional PCV13 | 34.9 (52.3) | 33.6 (50.0) | 42.6 (58.6) | 35.7 (51.9) | 26.7 | 22.8 | 29.2 | 31.4 | 34.9 | 33.2 | 44.8 | 38.1 | 45.6 | 49.6 | 60.2 | 52.4 |
| 19A | 66.8 (89.8) | 61.5 (86.2) | 78.9 (96.3) | 74.7 (91.2) | 50.0 | 41.3 | 52.2 | 63.7 | 64.8 | 56.9 | 73.3 | 70.3 | 73.9 | 80.7 | 91.9 | 86.8 |
| 3 | 0.0 (0.0) | 0.0 (0.0) | 0.0 (2.4) | 0.0 (6.2) | 0.0 | 0.0 | 0.0 | 0.0 | 6.0 | 5.0 | 15.5 | 12.5 | 6.0 | 8.3 | 14.3 | 14.1 |
| 7F | 0.0 (9.5) | 0.0 (0.0) | 0.0 (8.3) | 0.0 (0.0) | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 7.7 | 4.8 | 0.0 | 8.3 | 7.7 |
| PPSV23-nonPCV13 | 0.7 (10.4) | 0.0 (8.1) | 1.3 (15.7) | 0.5 (13.2) | 2.2 | 0.0 | 1.7 | 1.5 | 1.5 | 3.5 | 5.7 | 3.6 | 26.1 | 22.1 | 34.1 | 32.5 |
| 11A/11D | 0.0 (8.8) | 0.0 (2.4) | 0.0 (8.2) | 2.3 (6.8) | 2.9 | 0.0 | 2.0 | 2.3 | 0.0 | 0.0 | 2.0 | 4.5 | 35.3 | 19.5 | 34.7 | 27.3 |
| 22A/22F | 0.0 (6.5) | 0.0 (0.0) | 4.1 (14.3) | 0.0 (2.9) | 3.2 | 0.0 | 2.0 | 2.9 | 6.5 | 2.8 | 12.2 | 5.7 | 17.9 | 16.7 | 36.7 | 20.0 |
| 15B/15C | 0.0 (33.3) | 0.0 (33.3) | 2.1 (44.7) | 0.0 (36.2) | 0.0 | 0.0 | 2.1 | 0.0 | 0.0 | 5.6 | 6.4 | 2.1 | 46.7 | 38.9 | 61.7 | 53.2 |
| 17F | 0.0 (7.1) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (9.1) | 0.0 | 0.0 | 0.0 | 9.1 | 0.0 | 0.0 | 0.0 | 0.0 | 28.6 | 18.2 | 20.0 | 9.1 |
| 10A | 7.7 (15.4) | 0.0 (0.0) | 0.0 (5.0) | 0.0 (0.0) | 7.7 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 9.1 | 7.7 | 0.0 | 10.0 | 9.1 |
| 9N/9L | 0.0 (0.0) | 0.0 (4.5) | 0.0 (7.7) | 0.0 (4.8) | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 13.6 | 3.8 | 4.8 | 0.0 | 18.2 | 3.8 | 9.5 |
| 33F/33A/37 | 0.0 (0.0) | 0.0 (0.0) | 0.0 (7.1) | 0.0 (8.3) | 0.0 | 0.0 | 7.1 | 0.0 | 0.0 | 0.0 | 14.3 | 0.0 | 71.4 | 50.0 | 57.1 | 91.7 |
| Nonvaccineb | 1.9 (44.0) | 0.4 (47.6) | 0.5 (55.0) | 0.3 (52.8) | 1.9 | 0.0 | 1.6 | 0.9 | 15.5 | 18.1 | 16.9 | 14.5 | 33.3 | 37.6 | 42.9 | 37.0 |
| 6C/6D | 0.0 (60.0) | 0.0 (42.5) | 0.0 (59.4) | 0.0 (55.6) | 0.0 | 0.0 | 3.1 | 0.0 | 2.2 | 2.5 | 3.1 | 5.6 | 53.3 | 40.0 | 56.2 | 50.0 |
| 23A | 0.0 (45.2) | 0.0 (75.0) | 0.0 (70.4) | 0.0 (71.7) | 0.0 | 0.0 | 0.0 | 0.0 | 6.5 | 15.6 | 16.7 | 13.0 | 9.7 | 25.0 | 18.5 | 26.1 |
| 15A/15F | 0.0 (76.7) | 0.0 (97.5) | 0.0 (90.9) | 0.0 (88.2) | 0.0 | 0.0 | 0.0 | 0.0 | 80.0 | 92.5 | 95.5 | 88.2 | 86.7 | 95.0 | 97.7 | 94.1 |
| 23B | 0.0 (27.3) | 0.0 (27.3) | 2.7 (32.4) | 0.0 (44.2) | 0.0 | 0.0 | 2.7 | 0.0 | 0.0 | 4.5 | 5.4 | 9.3 | 13.6 | 4.5 | 27.0 | 11.6 |
| 35B | 5.0 (80.0) | 2.2 (91.1) | 1.4 (95.9) | 1.6 (91.8) | 5.0 | 0.0 | 2.7 | 4.9 | 5.0 | 4.4 | 4.1 | 1.6 | 40.0 | 60.0 | 62.2 | 54.1 |
| 16F | 6.7 (13.3) | 0.0 (0.0) | 0.0 (9.1) | 0.0 (6.2) | 6.7 | 0.0 | 4.5 | 0.0 | 0.0 | 0.0 | 9.1 | 6.2 | 0.0 | 13.0 | 9.1 | 6.2 |
| 31 | 7.7 (7.7) | 0.0 (0.0) | 0.0 (0.0) | 0.0 (0.0) | 7.7 | 0.0 | 0.0 | 0.0 | 15.4 | 0.0 | 0.0 | 5.0 | 23.1 | 27.8 | 26.1 | 25.0 |
| 35F/47F | 0.0 (0.0) | 0.0 (10.0) | 0.0 (0.0) | 0.0 (0.0) | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 10.0 | 27.3 | 12.5 |
| 34 | 0.0 (0.0) | 0.0 (0.0) | 0.0 (8.3) | 0.0 (9.1) | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 11.8 | 0.0 | 0.0 | 0.0 | 11.8 | 8.3 | 18.2 |
| 7C/7B/40 | 0.0 (20.0) | 0.0 (0.0) | 0.0 (10.0) | 0.0 (0.0) | 0.0 | 0.0 | 0.0 | 0.0 | 20.0 | 0.0 | 0.0 | 0.0 | 20.0 | 0.0 | 0.0 | 0.0 |
| Nontypeable | 0.0 (23.1) | 7.7 (61.5) | 0.0 (40.9) | 0.0 (13.3) | 0.0 | 0.0 | 0.0 | 0.0 | 15.4 | 30.8 | 13.6 | 0.0 | 23.1 | 53.8 | 40.9 | 33.3 |
| All | 13.3 (38.3) | 11.6 (38.8) | 15.0 (46.3) | 10.3 (41.3) | 10.7 | 7.7 | 10.9 | 9.7 | 18.9 | 19.8 | 23.5 | 18.0 | 35.7 | 38.1 | 46.6 | 40.1 |
a
Data represent percentages of nonsusceptible isolates according to the susceptible parenteral (≤2 μg/ml) (for nonmenigitis patients) and oral (≤0.06 μg/ml) (in parentheses) penicillin breakpoints for ceftriaxone (≤1 μg/ml), clindamycin (≤0.25 μg/ml), and erythromycin (≤0.25 μg/ml) published in the CLSI M100-S24 document.
b
“Nonvaccine” indicates those strains not present in the three vaccines available in the United States.