TABLE 3.

Interaction of DNA gyrases with QnrB1 and QnrB1 mutants having loop deletions^a

QnrB1 mutant	No. of expts	Fold change		P valuec
		Median (ratiob)	Interquartile range
Interaction with GyrA
Wild type	14	404 (1)	317–602
ΔloopA	5	372 (0.92)	161–844	0.893
ΔloopB	8	175 (0.43)	128–294	0.012
ΔloopA+B	8	104 (0.26)	56–230	0.012
Interaction with GyrB
Wild type	14	3,587 (1)	1,582–10,826
ΔloopA	6	2,621 (0.73)	1,523–6,572	0.028
ΔloopB	5	16,517 (4.60)	6,435–18,909	0.080
ΔloopA+B	5	14,242 (3.97)	6,797–25,222	0.080
Interaction with GyrBA
Wild type	9	3,777 (1)	2,368–5,436
ΔloopA	5	219 (0.06)	63–455	0.043
ΔloopB	9	3,285 (0.87)	2,419–6,625	0.441
ΔloopA+B	9	4,926 (1.30)	3,962–6,450	0.110

^aTable 3 is set up like Table 2 unless indicated otherwise. See Table 2 footnotes.

^bThe ratio is the median fold change in the mutant compared to that in the wild type.

^cA boldface P value indicates a statistically significant decrease in interaction.