TABLE 1.
Antimicrobial susceptibility patterns of K. pneumoniae KBu-1, the E. coli JM101 recipient, and the E. coli JM101 transformants
| Antimicrobial agent(s) | MICa (μg/ml) for: |
||
|---|---|---|---|
| K. pneumoniae KBu-1 | E. coli JM101 | E. coli JM101 transformantsb | |
| Imipenemc | 512 | 0.25 | 4 |
| Meropenemc | 512 | 0.03 | 4 |
| Ceftazidimec | 64 | 0.12 | 8 |
| Amoxicillin-clavulanic acid | >8 | 4 | >8 |
| Ampicillin-sulbactam | >32 | ≤8 | >32 |
| Cefepime | >32 | ≤1 | 2 |
| Cefotaxime | >4 | ≤0.06 | 4 |
| Piperacillin-tazobactam | >128 | ≤2 | 128 |
| Amikacin | ≤4 | ≤4 | ≤4 |
| Gentamicin | ≤1 | ≤1 | ≤1 |
| Colistin | ≤0.5 | ≤0.5 | ≤0.5 |
| Nitrofurantoin | >64 | ≤32 | ≤32 |
| Tigecycline | 1 | 0.25 | 0.25 |
| Trimethoprim-sulfamethoxazole | >4 | ≤0.5 | ≤0.5 |
| Ciprofloxacin | >2 | ≤0.06 | ≤0.06 |
| Levofloxacin | >4 | ≤1 | ≤1 |
a
Reported MIC values were determined by Sensititre plates (Trek Diagnostic Systems) with the exception of those of imipenem, meropenem, and ceftazidime.
b
E. coli JM101 transformed with the entire K. pneumoniae KBu-1 plasmid content and with the 13-kb band alone displayed the same susceptibility profile.
c
For these antibiotics, the CLSI standard microdilution method was used (12) in order to obtain a more precise evaluation.