TABLE 1.
Description of the influenza viral titer data used for model building
| Study reference | Study type | Intervention(s) used for modeling (no. of subjects) | Sampling scheme |
|---|---|---|---|
| Baccam | Inoculation of influenza A/Hong Kong/123/77 (H1N1) | Placebo (n = 6) | Nasal washings collected once daily for the first week of infection on days 1–8 |
| PV15616 | Inoculation of influenza A/Texas/36/91 (H1N1); phase II study | Placebo (n = 13); treatment (n = 56) with oseltamivir administered orally as multiple doses of 20, 100, or 200 mg b.i.d. or 200 mg q.d.a for 5 days | Nasal washings collected once prior to inoculation, then b.i.d. on days 1 and 2, and then once daily on days 3, 4, 5, 6, 7, and 8 |
| PV15615 | Inoculation of influenza A/Texas/36/91 (H1N1) | Placebo (n = 6) | Nasal washings collected once prior to inoculation and once daily for the first week of infection on days 1–8 |
| WV15670 | Naturally acquired influenza virus infection; phase III study | Placebo (n = 127) | Nasal washings collected once daily on days 2, 4, and 8 (some sites) and day 6 (all sites) |
a
q.d., once a day.