TABLE 1.
Neuraminidase inhibition by oseltamivir carboxylate and zanamivir
| Virus | IC50 (nM)a |
|
|---|---|---|
| Oseltamivir carboxylate | Zanamivir | |
| A/1621(H7N9)b (n = 1) | 0.45 ± 0.048 | 0.58 ± 0.010 |
| NA I222 (n = 3)c | 0.51 ± 0.12 | 0.50 ± 0.24 |
| NA I222T (n = 10)d | 4.1 ± 0.87 | 1.2 ± 0.41 |
a
Drug concentrations that reduced viral NA activity by 50% (IC50) in a fluorescence-based assay with the MUNANA substrate. Values are means ± SD from 1, 3, and 10 duplicate sample analyses.
b
Virus used for inoculation of mallards.
c
Virus isolated from fecal samples during the experiment, with wild-type isoleucine (I) at NA residue 222.
d
Virus isolated from fecal samples during the experiment, with a threonine (T) substitution at NA residue 222.