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Caspase implication in mitochondrial effects of compound 5 in A549 cells. Cells were cultured for 24 h in the presence of compound 5 at the indicated concentrations, alone (solid line) or combined with the general caspase inhibitor z-VAD-fmk (dashed line). Then, transmembrane mitochondrial potential was analyzed by flow cytometry after cells were stained with the probe DiOC6(3). Results are mean ± SD of two independent experiments with duplicates.
