Table 3. IC50 (μM) of Metal Complexes 1–5, Ligand COD, and Cisplatin in Human Cell Linesa.
| Jurkat | A549 | DU-145 | MiaPaca2 | MDA-MB-231 | HEK-293T | |
|---|---|---|---|---|---|---|
| 1 | 3.4 ± 0.5 | 85.3 ± 5.9 | 40 ± 8.1 | 81.8 ± 2.6 | 101.8 ± 16 | 14.6 ± 1.4 |
| 2 | 9.5 ± 0.07 | >125 | >125 | >125 | >125 | >125 |
| 3 | 2.13 ± 0.24 | 20.8 ± 1.7 | 22.5 ± 4.2 | 7.53 ± 5.0 | 14.6 ± 3.7 | 4.0 ± 0.42 |
| 4 | 0.43 ± 0.06 | 0.85 ± 0.29 | 0.93 ± 0.43 | 0.79 ± 0.09 | 0.39 ± 0.05 | 1.25 ± 0.25 |
| 5 | 0.53 ± 0.13 | 2.01 ± 0.89 | 0.81 ± 0.07 | 1.03 ± 0.06 | 0.84 ± 0.29 | 0.94 ± 0.07 |
| COD | >125 | >125 | >125 | >125 | >125 | >125 |
| cisplatin | 10.8 ± 1.2 | 114.2 ± 9.1 | 112.5 ± 33 | 76.5 ± 7.4 | 131.2 ± 18 | 69.0 ± 6.7 |
a
All compounds were dissolved in 1% DMSO and diluted with water before addition to cell culture medium for a 24 h incubation period. Cisplatin was dissolved in H2O. Data are expressed as mean ± SD (n = 4).