Table 5. Permeability Values Obtained by the Caco-2 Cell Monolayers Assaya.
| compound (20 μM) | Peff (cm/s) | SD |
|---|---|---|
| cisplatin | 5.44 × 10–7 | 4.66 × 10–7 |
| 4 | 4.62 × 10–6 | 3.54 × 10–6 |
| 5 | 2.71 × 10–5 | 5.00 × 10–6 |
| metoprolol | 2.32 × 10–5 | 1.75 × 10–6 |
| cimetidine | 1.86 × 10–6 | 3.71 × 10–7 |
| Lucifer Yellow | 1.90 × 10–7 | 4.98 × 10–8 |
a
Metoprolol, cimetidine, and Lucifer Yellow were used as model compounds of high, medium, and low oral permeability, respectively. Data correspond to the averaged values for three independent experiments.