Table 6. Absorption Rate Coefficients, Ka, and Permeability Values Obtained from in Situ Rat Assaysa.
| compound | Ka1 (h–1) | SD | Peff (cm/s) | SD |
|---|---|---|---|---|
| cisplatinb | ND | – | ND | – |
| 4b | 2.00 | ±0.11 | 4.72 × 10–5 | ±2.60 × 10–6 |
| 5b | 2.12 | ±0.22 | 5.50 × 10–5 | ±5.40 × 10–6 |
| metoprololc | 2.30 | ±0.15 | 5.40 × 10–5 | ±3.54 × 10–6 |
| cimetidinec | 1.68 | ±0.12 | 3.97 × 10–5 | ±3.04 × 10–6 |
| atenololc | 0.22 | ±0.02 | 5.19 × 10–6 | ±4.72 × 10–7 |
a
Metoprolol, cimetidine, and atenolol were used as model compounds of high, medium, and low oral permeability, respectively. Data correspond to values of six independent experiments. ND = not detectable.
b
20 μM.
c
100 μM.