Table 2. Association of WNT5A rs524153 and rs504849 variants with conotruncal malformations.
| SNPs | Genetic model | Pattern | Control | Case | P-value* | Pc-value# | OR (95% CI) |
|---|---|---|---|---|---|---|---|
| rs524153 | Codominant | AA/AC/CC | 336/351/111 | 138/133/25 | 0.026 | 0.052 | NA |
| Dominant | AA/AC + CC | 336/462 | 138/158 | 0.16 | 0.32 | 0.82 (0.63–1.08) | |
| Recessive | AA + AC/CC | 687/111 | 271/25 | 0.0086 | 0.017 | 0.56 (0.35–0.88) | |
| rs504849 | Codominant | AA/AG/GG | 339/347/112 | 139/132/25 | 0.024 | 0.048 | NA |
| Dominant | AA/AG + GG | 339/459 | 139/157 | 0.15 | 0.3 | 0.82 (0.63–1.08) | |
| Recessive | AA + AG/GG | 686/112 | 271/25 | 0.0076 | 0.015 | 0.55 (0.35–0.87) |
*Adjusted by sex.
#corrected P value (after Bonferroni multiple adjustment); OR = odds ratio; CI = confidence interval; NA = not available.