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Distinct bacterial lineages reduce diabetes incidence in gnotobiotic MyD88-negative NOD mice. Bona fide insulitis (percentage of total islets) in 13-wk-old female MyD88+/+ or MyD88−/− mice in SPF and GF conditions and colonized with ASF, VSL3, or SFB. n = number of mice per group. P values for histopathology were determined by Student’s t test. *P < 0.05, **P < 0.01, ***P < 0.001.
