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A stronger 5′ splice-site on exon 7 prevents U2AF65 effects on exon 7 splicing. (A) The splice-site sequences of wild type, 5′E7-E6, and 5′E7-con are shown. (B) RT-PCR analysis from SMN1-5′E7-E6 and SMN2-5′E7-E6 minigenes harboring cells that were expressed with Flag-U2AF65. (C) RT-PCR analysis with RNAs extracted from SMN1-5′E7-con and SMN2-5′E7-con minigenes, along with the Flag-U2AF65 minigene.
