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U2AF65 promotes its own binding only on the weaker polypyrimidine tract in SMN pre-mRNA. (A) Py tract sequences of exon 7 (Py7) and exon 8 (Py8) are shown. (B) UV-crosslinking and immunoprecipitation with anti-U2AF65 antibody were performed using Py7 and Py8 RNA after incubation with cell lysate that is expressed with U2AF65. Immunoblotting analysis using an anti-flag antibody is shown.
