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Reduced expression of U2AF65 promotes exon 10 inclusion of Tau pre-mRNA. (Upper) RT-PCR results of endogenous Tau pre-mRNA are shown from U2AF65-shRNA-treated SH-SY5Y cells. GAPDH was used as a loading control. Quantitation results of SMN2 pre-mRNA splicing are shown. Immunoblotting analysis of these cells using anti-U2AF65 (MC3) antibody are shown, with α-tubulin as a control. (Lower) The scheme of Tau pre-mRNA is shown.
