Table S1.
Gene ontology of antigens selected for predicting days since an individual was last infected with Pf
| Rank | Gene identification | Description | Stage expressed* | Cellular component† | Function | |||||||||
| L | S | IE | M | G | HC | MC | CS | I | A | SCV | ||||
| 1 | PF3D7_1002000 | Plasmodium exported protein, hyp2 | X | X | X | X | ||||||||
| 2 | PF3D7_0402400 | Plasmodium exported protein, GEXP18 | X | X | X | X | Nucleotide binding | |||||||
| 3 | PF3D7_1106300 | Exonuclease, putative | X | X | Exonuclease activity; nucleic acid binding | |||||||||
| 4 | PF3D7_0711700 | Erythrocyte membrane protein 1 | X | X | X | X | Cell adhesion molecule binding; receptor activity; antigenic variation | |||||||
| 5 | PF3D7_0800300 | Erythrocyte membrane protein 1 | X | X | X | Cell adhesion molecule binding; receptor activity; antigenic variation | ||||||||
| 6 | PF3D7_0501100.1 | Heat shock protein 40, type II | X | X | X | X | X | Heat shock protein binding; unfolded protein binding | ||||||
| 7 | PF3D7_0423700 | Early transcribed membrane protein 4 | X | X | X | |||||||||
| 8 | PF3D7_1020800 | Dihydrolipoamide acyltransferase component E2 | X | X | X | Dihydrolipoyllysine residue acetyltransferase activity; pyruvate dehydrogenase (acetyl-transferring) activity | ||||||||
| 9 | PF3D7_0731600 | Acyl-CoA synthetase | X | X | X | X | AMP binding; long-chain fatty acid-CoA ligase activity; catalytic activity | |||||||
| 10 | PF3D7_1002100 | PF70 protein | X | X | X | |||||||||
| Top 20 | PF3D7_0223300 | Erythrocyte membrane protein 1 | ||||||||||||
| PF3D7_0532100 | Early transcribed membrane protein 5 | X | X | |||||||||||
| PF3D7_0702300 | Sporozoite threonine and asparagine-rich protein | X | X | X | X | |||||||||
| PF3D7_0800200 | Erythrocyte membrane protein 1 | X | X | X | X | X | Cell adhesion molecule binding; receptor activity; antigenic variation | |||||||
| PF3D7_0801000 | Plasmodium exported protein | X | X | X | X | |||||||||
| PF3D7_0936300 | Ring-exported protein 3 | X | X | |||||||||||
| PF3D7_1033200 | Early transcribed membrane protein 10.2 | X | X | X | X | X | ||||||||
| PF3D7_1129100 | Parasitophorous vacuolar protein 1 | X | X | X | X | X | GTPase activator activity; protein binding | |||||||
| PF3D7_1300300 | Erythrocyte membrane protein 1 | X | X | X | X | Cell adhesion molecule binding; receptor activity; antigenic variation | ||||||||
| PF3D7_1353100 | Plasmodium exported protein | X | X | X | X | |||||||||
| Top 30 | PF3D7_0304600 | CSP | X | X | ||||||||||
| PF3D7_0414700 | GTP binding protein, putative | X | X | X | GTP binding; ferrous iron transmembrane transporter activity | |||||||||
| PF3D7_0420700 | Erythrocyte membrane protein 1 | X | X | X | Cell adhesion molecule binding; receptor activity; antigenic variation | |||||||||
| PF3D7_0532400 | Plasmodium exported protein, PHISTb | X | X | X | ||||||||||
| PF3D7_0620400 | MSP10 | X | X | X | X | Attachment of GPI anchor to protein | ||||||||
| PF3D7_0808600 | Erythrocyte membrane protein 1 | X | X | X | Cell adhesion molecule binding; receptor activity; antigenic variation | |||||||||
| PF3D7_1024800 | Conserved Plasmodium protein | X | X | X | X | X | X | Hydrolase activity | ||||||
| PF3D7_1133400 | AMA1 | X | X | X | X | X | Host cell surface binding; protein binding | |||||||
| PF3D7_1438100 | Secretory complex protein 62 | X | X | X | X | X | X | Protein binding; protein transporter activity; intracellular signal transduction | ||||||
| PF3D7_1477500 | Plasmodium exported protein | X | X | X | ||||||||||
GPI, glycosylphosphatidylinositol.
*
Stage expressed by mass specification: liver (L), sporozoite (S), intraerythrocytic (IE), merozoite (M), and gametocyte (G).
†
Cellular component: exported to host cell (HC), Maurer’s cleft (MC), membrane/cell surface (CS), intracellular/cytoplasm/nucleus (I), apicoplast (A), and symbiont-containing vacuole (SCV).