Table S4.

Multivariate analysis by COX proportional hazard model (n = 60)

Factors	PFS			OS
	P	HR	95% CI	P	HR	95% CI
Sex (male vs. female)	0.360	1.63	0.572–4.648	0.753	0.807	0.213–3.062
Age (≤65 vs. >65)	0.013	2.180	1.183–4.018	0.012	2.750	1.254–6.031
Smoking status (never/light vs. ever/current)	0.238	1.736	0.694–4.346	0.769	1.180	0.390–3.574
Type of EGFR-TKI (gefitinib vs. erlotinib)	0.877	0.948	0.483–1.863	0.184	1.930	0.732–5.089
Line of EGFR-TKI (first line vs. second and more than line)	0.762	0.898	0.447–1.804	0.012	0.347	0.153–0.790
EGFR mutation status (wild type vs. mutant type)*	0.023	0.500	0.275–0.909	0.260	0.651	0.309–1.373

^*EGFR mutation types included the EGFR 19del and 21L858R mutations.