Figure 5. P53 suppresses and AID promotes Plasmodium induced lymphoma.

A- Survival of Plasmodium infected mice. All mice are also CD19^cre/+.

B- Spleen histology of Plasmodium infected CD19^cre/+p53^lox/lox mice. L4 is AID proficient lymphoma and S2 is AID deficient benign B cell hyperplasia with marked extramedullary hematopoiesis.

C- Lymphoma versus benign hyperplasia in Plasmodium infected mice. Lymphoid tissues were evaluated by histology, immunohistochemistry, and flow cytometry. “Benign hyperplasia” indicates mice with splenomegaly but normal B cell distribution, with B220⁺ cells confined to follicular areas. “Atypical hyperplasia or early neoplasia” denotes splenomegaly and B220⁺ cells expanding into the periarteriolar lymphoid sheats (PALS). “Lymphoma” defines abnormal lymphoid tissue architecture and/or dissemination to multiple organs.

D- Extramedullary hematopoiesis in Plasmodium infected mice. Spleen sections were evaluated for the degree of extramedullary hematopoiesis.

See also Figure S5 and Table S2.