Table 1. Karyotype and phenotype of lymphomas in P. chabaudi infected CD19cre/+ p53lox/lox mice.
Translocations are clonal if present in all metaphases. In italic are sporadic translocations and bolded are clonal, reciprocal translocations. At least 20 metaphases analyzed for each tumor.
| Tumor ID | Karyotype | Phenotype | S | MLN | sbLN | oLN | L |
|---|---|---|---|---|---|---|---|
| L21 | ND | CD3+ | + | − | − | − | + |
| L4 | T(11;15) T(8;17) T(12;11) T(15;19) | CD19+ IgM− IgD− IgK+ CD138− CD38+/− FAS− GL7− | + | + | + | + | − |
| L9 | no metaphases | CD19+ IgM− IgD− IgK+ CD138− CD38+ FAS+ GL7− | + | + | + | + | − |
| L23 | T(12;15) T(18;3) | CD19− IgM− IgD− IgK− CD138+ CD38− FAS-GL7dim | + | − | − | − | + |
| L24 | T(3;11) T(18;1) | CD19+ IgM− IgD− IgK+ CD138+ CD38+ FASdim GL7− | + | + | + | + | − |
| L33 | T(2;16) | CD19+ IgM+ IgD− IgK+ CD138+ CD38+ FAS+ GL7− | + | + | + | + | − |
| L52 | no metaphases | CD19+ IgM− IgD− IgK+ CD138− CD38+/− FAS− GL7+ | + | − | − | + | − |
| L62 | T(8;13) T(3;17;3;4) | CD19+ IgM+ IgD− IgK+ CD138+ CD38+ FAS+ GL7dim | + | + | + | + | − |
| L68 | ND | CD19− IgM− IgD− IgK− CD138+ CD38+ FASdim GL7− | − | + | + | + | − |
| L31 | T(2;10) | CD19+ IgM+ IgD+ IgK+ CD138− CD38+ FASdim GL7− | + | + | + | + | + |
| L39 | T(7;13) | CD19+ IgM+ IgD− IgK+ CD138− CD38+ FAS+ GL7+ | + | − | − | + | + |
| L69 | ND | CD19+ IgM+ IgD+ IgK+ CD138− CD38+ FAS− GL7− | + | − | − | − | − |
Macroscopic tumor dissemination at necropsy: S = spleen; MLN = mesenterial lymph nodes; sbLN = submandibular lymph nodes; oLN = axillary, thoracal or inguinal (other) lymph nodes; L = liver or other metastasis. ND is not determined. See also Figure S6 and Table S2.