Table 2.

${\mathrm{E}\mathrm{C}}_{50}^{\mathrm{drug},\mathrm{D}3}$ and ${\mathrm{E}\mathrm{C}}_{50}^{\mathrm{drug},\mathrm{D}2}$ for GSK618334 estimated before and after motion correction (MC)

MC Method	Removal of unrealistic BPND data points	${\mathrm{E}\mathrm{C}}_{50}^{\mathrm{drug},\mathrm{D}3}$ of GSK618334 (ng/ml)	${\mathrm{E}\mathrm{C}}_{50}^{\mathrm{drug},\mathrm{D}2}$ of GSK618334 (ng/ml)
No MC	Required	15 (−6, 37)	529 (206, 852)
MC by FBF	Required	4 (0, 8)	492 (327, 658)
MC by GIR	Not necessary	10 (5, 15)	539 (419, 660)

Values in parentheses indicate 95 % confidence intervals associated with the parameter estimates