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. 2015 Apr 29;43(14):6814–6826. doi: 10.1093/nar/gkv392

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 1. — Regulation of Tet1 in mouse ES cells. (A) Genomic view of RNA-seq and H3K4me3 in MEFs and mouse ESCs together with reconstructed Tet1 gene structure. (B) Isoform-specific RT-qPCR of Tet1 mRNA in the indicated samples. (C) qPCR of ChIP analysis for the indicated transcriptional factors on Tet1.1 promoter in mESCs. (D) Isoform-specific RT-qPCR of Tet1 mRNA in ESCs cultured without LIF for the indicated times. (E) Isoform-specific RT-qPCR of Tet1 mRNA in control and cMyc/Mycn, Nanog and Oct3/4 knockdowns ESCs. Error bars represent the standard deviation of three independent experiments. P-value was calculated by using t-test. (* = P-value < 0.01).