Figure 8.

Pax6-dependent gene regulatory networks and analysis of enhancers of key regulatory genes in forebrain. (A) GRN of early stages of cortical neurogenesis. (B) GRN of cell cycle exit control in radial glial cells. (C) Dual roles of Pax6 in a subcircuit that indirectly controls expression of Tbr1 and Bhlhb5. (D) Direct repression of Ascl1 and Grx2 in the boundary region. Pax6 direct targets identified (validated) here are shown in blue (green), respectively. Pax6-binding in both forebrain and lens, and distribution of histone PTMs and RNA polymerase II is shown in Supplementary Figure S5.