Table 1. Distribution of Pax6 peaks with multiple (n ≤ 4) PD or HD motifs in forebrain and lens chromatin.
| Tissue | % of peaks (n) with multiple paired domain (PD) motifs | % of peaks (n) with multiple homeodomain (HD) motifs | % of peaks with PD and HD motifs | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| n | 4 | 3 | 2 | 1 | 0* | 4 | 3 | 2 | 1 | 0* | N/A |
| Forebrain | 0.1 | 1.6 | 14.8 | 51.3 | 32.3 | 0 | 0.5 | 5.1 | 27.4 | 66.9 | 23 |
| Lens | 0.1 | 1.1 | 14.2 | 52.5 | 32.1 | 0 | 0.1 | 2.0 | 19.2 | 78.6 | 27 |
*) There are at least two possibilities to explain the finding that no Pax6 PD, or HD motifs were identified in a certain number of peaks. First, there are Pax6-binding sites with lower level of sequence conservation (24). Second, some peaks are the result of promoter-enhancer looping and the actual binding site is not present in the DNA that was immunoprecipitated from the crosslinked chromatin.
Not applicable, N/A.