Fig. 2.

Characterization of hepatic and serum lipids in control and binge EtOH-fed male and female hPXR mice. Male and female hPXR mice were orally administered saline (control, □) or EtOH (4.5 g/kg; ▪) every 12 hours for a total of three doses and were killed 4 hours after the final dose. H&E staining (original magnification, 400×) (A), hepatic triglyceride (B), hepatic cholesterol (C), serum triglyceride (D), and serum NEFA levels (E) were assayed as described in Materials and Methods. Steatosis (indicated by arrows) in both male and female hPXR mice fed EtOH. Data represent the mean ± S.E.M. (n = 5–6). ^#P < 0.05 between male and female mice treated with saline (control) and EtOH.