Fig. 6.

(Left) Effects of Δ⁹-THC on percentage of responses that occurred on the Δ⁹-THC–associated aperture (A) and response rate (B) in mice trained to discriminate Δ⁹-THC from vehicle in a nose poke procedure following transition from a lever press procedure (filled squares) or de novo (unfilled squares). Each point represents the mean (±S.E.M.) of data for seven male C57/BL6J mice for the transitional group and n = 11–13 for the de novo group. (Right) Effects of Δ⁹-THC (filled squares), AB-PINACA (unfilled squares), AB-CHMINACA (filled circles), and FUBIMINA (unfilled circles) on percentage of responses that occurred on the Δ⁹-THC–associated aperture (C) and response rate (D). Each point represents the mean (±S.E.M.) of data for 18–20 male C57/BL6J mice for Δ⁹-THC and n = 6–9 for the synthetic compounds, except for % Δ⁹-THC–associated aperture responding at 3 mg/kg AB-PINACA (n = 2) and 1 mg/kg AB-CHMINACA (n = 1). Asterisks (*) indicate significant differences compared with respective vehicle.