TABLE 3.
Potencies for substitution in Δ9-THC discrimination
ED50 (±95% CIs) are expressed in μmol/kg. Molecular weights are provided in parentheses. All compounds were administered intraperitoneally.
| Compound | CB1 Ki | ED50 |
|---|---|---|
| nM | μmol/kg | |
| THC DD (lever) | ||
| Δ9-THC (n = 7) | 41a | 4.5 |
| (314) | (2) | (3.5–5.7) |
| JWH-018 (n = 11) | 9.5a | 0.35 |
| (341) | (4.5) | (0.32–0.50) |
| CP47,947 (n = 8) | 9.5b | 0.85 |
| (318) | (0.35) | (0.47–1.45) |
| WIN 55,212-2 (n = 3) | 1.9a | 0.80 |
| (522) | (0.1) | (0.46–1.38) |
| THC DD (nose poke) | ||
| Δ9-THC (n = 20) | 41a | 5.7 |
| (314) | (2) | (4.8–6.7) |
| AB-CHMINACA (n = 8) | 0.78 | 0.34 |
| (356) | (0.11) | (0.22–0.50) |
| AB-PINACA (n = 9) | 2.87 | 3.78 |
| (330) | (0.69) | (2.42–5.87) |
| FUBIMINA (n = 6) | 296.1 | 131 |
| (360) | (33.5) | (72–233) |