Fig. 1.
SCH39166 inhibits ΔFosB induction by repeated THC treatment. Pretreatment with the D1R antagonist SCH39166 inhibited induction of ΔFosB by repeated THC treatment in the prefrontal cortex (A), caudate-putamen (B), nucleus accumbens (C), and amygdala (D). ΔFosB-ir is expressed as mean percentage of saline/vehicle-treated mice ± S.E.M. (n = 7–8 per group). (E) Comparisons of induction of ΔFosB by THC expressed as mean percentage of vehicle ± S.E.M. in saline- and SCH39166-pretreated mice. (F) Representative immunoblots. **P < 0.01, ***P < 0.001 compared with saline/vehicle mice (A–D); *P < 0.05 and **P < 0.01 compared with saline by Student’s t test (E). AMY, amygdala; CPU, caudate-putamen; NAc, nucleus accumbens; PFC, prefrontal cortex.