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. 2015 Sep;354(3):316–327. doi: 10.1124/jpet.115.224428

Fig. 4.

Fig. 4.

Effect of genetic deletion of DARPP-32 on ΔFosB expression in the striatum of mice treated acutely or repeatedly with THC. Genetic deletion of DARPP-32 attenuated ΔFosB expression measured after acute THC (VEH-THC) but not repeated THC (THC-THC) or vehicle (VEH-VEH) administration in the caudate-putamen (A) and nucleus accumbens (B). Representative immunoblots are shown above each graph. Data are expressed as mean percentage of VEH-VEH–treated WT mice ± S.E.M. (n = 7 per group). *P < 0.05 and ***P < 0.001 compared with WT control within the same treatment condition.