TABLE 1.
Emax and EC50 values of CP55,940-stimulated [35S]GTPγS binding
Data are mean Emax and EC50 values ± S.E.M. (n = 5), derived from nonlinear regression analysis of the CP55,940 concentration-effect curves shown in Fig. 6.
| DARPP-32 WT |
DARPP-32 KO |
|||
|---|---|---|---|---|
| Emax | EC50 | Emax | EC50 | |
| %Stim. | nM | %Stim. | nM | |
| Nucleus accumbens | ||||
| Vehicle | 72.7 ± 3.1 | 5.8 ± 3.7 | 71.5 ± 5.6 | 5.0 ± 1.5 |
| THC | 45.6 ± 4.4a | 8.1 ± 3.6 | 41.0 ± 3.3a | 15.6 ± 8.7 |
| Caudate-putamen | ||||
| Vehicle | 66.4 ± 3.9 | 5.5 ± 3.1 | 63.3 ± 5.1 | 5.4 ± 3.8 |
| THC | 49.3 ± 3.3 | 3.7 ± 1.5 | 51.1 ± 8.2 | 2.9 ± 0.8 |
a
P < 0.001 different from vehicle-treated mice of the same genotype.