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. 2015 Jul 18;13:51. doi: 10.1186/s12915-015-0148-y

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© Chiang et al. 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Organization of the C. elegans hermaphroditic gonadal arm. A mitotic zone (MZ) contains stem cells at the distal end, which ensure organ self-renewal as cells are consumed proximally for spermatogenesis (during larval development) or oogenesis and apoptosis (during adulthood). Differentiation of mitotic cells is controlled by opposing factors such as FBF-1/2 and GLD-1, expressed in opposing gradients. The cell cycle regulator cyclin E1 (CYE-1) is expressed throughout the MZ. Subregions are shown that are considered in cell cycle analysis: distal-most mitotic zone (DMMZ), medial mitotic zone (MMZ), and proximal mitotic zone (PMZ). Cell position can be measured by the number of rows to the distal end (rows 1 to 19 are numbered)