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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Alcohol. 2015 Mar 6;49(3):237–243. doi: 10.1016/j.alcohol.2015.02.003

Figure 1. Ethanol withdrawal induces anxiety-like behavior without affecting locomotion in the open field arena.

Figure 1

Mice were treated chronically with either control and ethanol injections (A, B) or liquid diet (C, D). Locomotor behavior was not altered by ethanol withdrawal (A, C) but produced a significant decrease in the center ratio (distance traveled in center zone/total distance traveled; B and D). **p<0.05 compared to control-treated mice as measured by student t-test. N’s are 13, 9 for injections and 13, 13 for liquid diet.