Table 1.
Evaluation of the association between specific histopathologic characteristics [fibromyxoid stroma (FMX) and infiltrative invasion] and outcomes of recurrence and lymph node metastasis. Adjusted odds ratio estimates were obtained using multivariable (MV) logistic regression models which, in addition to histopathology, included age, race and depth of invasion (DOI).
| Unadjusted Estimates | Adjusted Estimates | |||||
|---|---|---|---|---|---|---|
| Model A1 | Model B2 | |||||
| OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | |
| LN Metastasis | ||||||
|
| ||||||
| FMX | 2.59 (1.06, 6.30) | 0.0364 | 2.43 (0.98, 6.05) | 0.1913 | 2.16 (0.85, 5.50) | 0.1049 |
| Infiltrative | 1.52 (0.64, 3.60) | 0.3441 | 1.38 (0.57, 3.37) | 0.4761 | 1.14 (0.45, 2.90) | 0.7809 |
| Both3 | 1.99 (0.83, 4.77) | 0.1235 | 1.83 (0.74, 4.57) | 0.1924 | 1.58 (0.62, 4.05) | 0.3418 |
| Either4 | 2.03 (0.83, 5.01) | 0.1222 | 1.89 (0.76, 4.73) | 0.1726 | 1.61 (0.63, 4.15) | 0.3199 |
|
| ||||||
| Recurrence | ||||||
|
| ||||||
| FMX | 2.25 (1.06, 4.77) | 0.0348 | 2.16 (1.01, 4.61) | 0.0470 | 1.95 (0.89, 4.24) | 0.0935 |
| Infiltrative | 2.15 (1.01, 4.55) | 0.0459 | 2.08 (0.94, 4.18) | 0.0571 | 1.86 (0.85, 4.06) | 0.1214 |
| Both3 | 2.68 (1.25, 5.76) | 0.0113 | 2.58 (1.19, 5.57) | 0.0159 | 2.33 (1.06, 5.15) | 0.0360 |
| Either4 | 1.87 (0.84, 3.70) | 0.1038 | 1.81 (0.85, 3.86) | 0.1265 | 1.60 (0.73, 3.51) | 0.2410 |
1
Estimates are adjusted for age and race.
2
Estimates are adjusted for age, race and DOI.
3
“Both” refers to samples having both FMX and Infiltrative characteristics versus those having only one or neither of the characteristics.
4
“Either” refers to samples having both or only one FMX or Infiltrative characteristics versus those having neither.