Table II.

Effects of combining thioridazine (THZ) and cefazolin (CEF) on the size of experimental cutaneous staphylococcal abscesses in mice. Numbers after each drug designation represent doses (in mg/kg) given intraperitoneally (for THZ) or subcutaneously (for CEF) on the day before inoculation, one hour before inoculation with S. aureus (ATCC BAA-1680), and each day after until sacrifice for THZ or each day after inoculation until sacrifice for CEF. Animals were sacrificed on day 3 after inoculation and abscess sizes determined then. A positive effect of the combination was taken as an abscess size significantly smaller than that obtained with either drug alone. Note that none of the combinations produced significantly smaller abscesses than those obtained with either drug alone.

Treatment	Abscess size	Effect
Control	32.2±4.8	–
THZ3	27.9±7.2	–
THZ10	13.3±2.0	–
CEF25	52.8±10.5	–
CEF50	14.5±4.5	–
THZ3+CEF25	36.1±5.8	None
THZ3+CEF50	13.3±3.7	None
THZ10+CEF 25	22.4±6.2	None
THZ10+CEF 50	12.7±4.8	None