Table 2.
Adjusted Hazard Ratios (HRs) for death in relation to BMI categories and weight change status for NHL cases, Connecticut, 1996–2000
| NHL overall
|
DLBCL
|
FL
|
CLL/SLL
|
|||||
|---|---|---|---|---|---|---|---|---|
| No. deaths/cases | HR | No. deaths/cases | HR | No. deaths/cases | HR | No. deaths/cases | HR | |
| Baseline BMI | ||||||||
| <18.5 | 5/6 | 2.84(1.12–7.15) | 0 / 0 | -- | 3 / 3 | 18.72(4.74–73.95) | 0 / 1 | -- |
| 18.5–24.9 | 111 / 266 | 1 | 36 / 80 | 1 | 18 / 61 | 1 | 20 / 36 | 1 |
| 25–30 | 78 / 185 | 0.98(0.73–1.31) | 27 / 65 | 0.70(0.41–1.20) | 16 / 39 | 1.29(0.63–2.66) | 9 / 18 | 2.43(0.92–6.42) |
| >=30 | 58 / 116 | 1.38(0.99–1.93) | 21 / 37 | 1.77(0.98–3.21) | 12 / 30 | 1.23(0.54–2.80) | 4 / 8 | 0.91(0.22–3.81) |
| BMI before treatment§ | ||||||||
| <18.5 | 6 / 9 | 0.98(0.39–2.43) | 0 / 1 | -- | 4 / 4 | 5.79(1.13–29.61) | 0 / 2 | -- |
| 18.5–24.9 | 48 / 93 | 1 | 8 / 17 | 1 | 6 / 19 | 1 | 16 / 24 | 1 |
| 25–30 | 22 / 67 | 0.55(0.33–0.92) | 1 / 6 | -- | 11 / 28 | 0.80(0.24–2.65) | 4 / 9 | 1.53(0.41–5.74) |
| >=30 | 17 / 49 | 0.62(0.34–1.12) | 1 / 7 | -- | 3 / 13 | 0.56(0.11–2.99) | 0 / 6 | -- |
| Pre-diagnostic weight change* | ||||||||
| <0 | 57 / 99 | 1.42(1.02–1.97) | 13 / 24 | 1.02(0.51–2.02) | 11 / 19 | 1.34(0.62–2.93) | 9 / 12 | 6.63(1.59–27.62) |
| 0 | 107 / 243 | 1 | 37 / 86 | 1 | 20 / 55 | 1 | 15 / 27 | 1 |
| >0 | 73 / 176 | 1.04(0.77–1.41) | 28 / 57 | 1.23(0.73–2.06) | 14 / 45 | 0.60(0.27–1.32) | 9 / 21 | 2.67(0.85–8.45) |
| Post-diagnostic weight change before treatment# | ||||||||
| <0 | 43 / 76 | 1.45(0.84–2.50) | 6 / 15 | 1.64(0.18–14.76) | 7 / 15 | 1.36(0.40–4.65) | 12 / 17 | 1.34(0.34–5.31) |
| 0 | 24 / 65 | 1 | 2 / 6 | 1 | 6 / 20 | 1 | 7 / 13 | 1 |
| >0 | 26 / 77 | 0.99(0.56–1.76) | 2/ 10 | -- | 11 / 29 | 0.92(0.29–2.93) | 1 / 11 | -- |
| Post-diagnostic weight change after treatment$ | ||||||||
| <0 | 67 / 126 | 1.98(1.14–3.45) | 31 / 55 | 1.42(0.61–3.31) | 6 / 15 | 1.17(0.20–6.95) | 5 / 8 | 14.77(0.36–607.47) |
| 0 | 17 / 64 | 1 | 8 / 23 | 1 | 3 / 15 | 1 | 1 / 5 | 1 |
| >0 | 37 / 92 | 1.85(1.04–3.32) | 16 / 39 | 1.44(0.60–3.49) | 8 / 25 | 1.22(0.25–5.83) | 5 / 5 | 1.01(0.04–22.69) |
Models were adjusted for age (continuous), education (high school or less, some college, and college graduate or more), stage (I, II, III, IV, and unknown), B-symptom (yes, no/unknown), initial treatment (none, radiation only, chemotherapy-based regimen, and other) and smoking (never, ever).
BMI at interview, only cases interviewed before treatment (n=218) were included.
Weight one year prior to interview-usual weight, only cases interviewed within one year after diagnosis (n=518) were included.
Weight change = weight at interview - usual weight, only cases interviewed before treatment (n=218) were included.
Weight change = weight at interview - usual weight, only cases interviewed after treatment (n=282) were included.