Fig. 2.

CAV development in cardiac allografts in Rag-1 deficient recipients. BALB/c mouse heart allografts in Rag-1^−/− B6 mouse recipients were harvested on POD 100. CAV was evaluated in H&E stained paraffin sections. Data are presented as a typical image of vascular lesion in the arteries. a Heart grafts from naïve Rag-1^−/− recipients—lack of T_mem cells (Group 1, n =3). b Heart grafts from Rag-1^−/− recipients harboring T_mem cells (Group 2, n =8), showing severe CAV. c Heart grafts from Rag-1^−/− recipients harboring T_mem cells and receiving anti-OX40L mAb treatment (Group 3, n =8)