Table 1.
The age of RA onset | Comorbidity | Immunoserology | Actual clinical status | DMARD therapy | Response to DMARD | Corticosteroids (mg PED) | Biological therapy | Response to biology therapy | Psoriatic arthritis |
---|---|---|---|---|---|---|---|---|---|
63 yrs | Hypertension | ANA, ACPA | Remission | Sulfasalazine-leukopenia, oral methotrexate-gastrointestinal side effect, cyclosporine-with golimumab | Nonresponder | — | Golimumab | Remission | Axial |
| |||||||||
46 yrs | — | RF, ACPA, ANA | Remission | Oral methotrexate-ineffective, sulfasalazine-gastrointestinal side effect | Nonresponder | — | Etanercept | Remission | Peripheral |
| |||||||||
59 yrs | Systemic sclerosis | RF, ACPA, ANA | Remission | Chloroquine-gastrointestinal side effect sulfasalazine | Nonresponder | — | Adalimumab-ineffective, rituximab | Remission | Peripheral |
| |||||||||
32 yrs | Hypertension | RF, ACPA, ANA | Active polyarthritis | Oral methotrexate-bone marrow toxicity azathioprine-ineffective cyclosporine-ineffective combination of chloroquine, sulfasalazine, oral methotrexate-GI side effect subcutaneous methotrexate | Ineffective | >7.5 continuously | Adalimumab-ineffective etanercept-ineffective golimumab-ineffective | Nonresponder | Peripheral and axial |
| |||||||||
40 yrs | Sjögren's syndrome, neurofibromatosis | RF, ACPA, ANA, aCL IgM | Severe glandular symptoms, active polyarthritis | Leflunomide-ineffective, oral methotrexate-hepatotoxicity | Nonresponder | — | Etanercept | Just started | Peripheral |
RA: rheumatoid arthritis, ANA: anti-nuclear antibody, ACPA: anti-citrullinated peptide antibody, aCL IgM: anti-cardiolipin antibody immunoglobulin M, DMARD: disease-modifying antirheumatic drugs, and PED: prednisolone equivalent dose.