Table 2.
Anti-HLA Ab profiles of the RA patients with or without ILD.
| BEADS# | NC | ILD(+)RA | ILD(−)RA | P | |
|---|---|---|---|---|---|
| Class I | 003 | 18.1 | 101.6 (92.7) | 205.3 (574.8) | 0.3796 |
| Class I | 004 | 23.6 | 83.5 (63.0) | 228.3 (422.1) | 0.5240 |
| Class I | 005 | 24.6 | 107.9 (79.3) | 276.4 (856.9) | 0.4384 |
| Class I | 009 | 25.9 | 118.7 (131.6) | 263.0 (751.2) | 0.3613 |
| Class I | 011 | 69.2 | 145.7 (69.9) | 381.9 (1086.8) | 0.4183 |
| Class I | 014 | 29.6 | 113.2 (79.1) | 251.4 (584.6) | 0.5698 |
| Class I | 016 | 34.4 | 119.9 (79.6) | 104.4 (147.4) | 0.1965 |
| Class I | 017 | 16.4 | 70.9 (39.3) | 121.6 (167.5) | 0.6668 |
| Class I | 046 | 26.2 | 94.3 (67.0) | 301.8 (964.6) | 0.3613 |
| Class I | 049 | 30.8 | 124.6 (143.5) | 197.9 (478.5) | 0.3987 |
| Class I | 077 | 18.0 | 89.7 (70.3) | 269.3 (855.1) | 0. 4181 |
| Class I | 078 | 21.0 | 65.9 (66.7) | 182.1 (574.1) | 0.2931 |
| Class II | 050 | 20.3 | 86.8 (99.8) | 176.0 (536.1) | 0.1339 |
| Class II | 053 | 102.9 | 283.3 (305.1) | 278.2 (353.4) | 0.7697 |
| Class II | 056 | 44.0 | 187.5 (239.4) | 188.7 (337.1) | 0.2779 |
| Class II | 057 | 50.1 | 164.8 (159.6) | 484.3 (1635.2) | 0.1630 |
| Class II | 059 | 28.3 | 163.0 (245.4) | 196.4 (504.5) | 0.1339 |
| MICA | 074 | 27.7 | 139.2 (280.6) | 30.5 (19.8) | 0.0014 |
| MICA | 075 | 19.5 | 348.7 (1060.5) | 69.2 (157.4) | 0.0026 |
| Average | |||||
| Class I | 28.2 | 103.0 (70.7) | 231.9 (610.0) | 0.6419 | |
| Class II | 49.1 | 177.1 (194.4) | 264.7 (665.6) | 0.2486 | |
| Class I, Class II | 34.3 | 124.8 (85.3) | 241.6 (470.4) | 0.5934 | |
| MICA | 23.6 | 244.0 (669.3) | 49.8 (80.0) | 0.0013 | |
| Ratio of average | |||||
| MICA/Class I | 0.8 | 1.7 (2.9) | 0.4 (0.3) | 4.47 × 10−5 | |
| MICA/Class II | 0.5 | 1.7 (3.7) | 0.7 (1.7) | 0.0040 | |
| MICA/(Class I, Class II) | 0.7 | 1.6 (3.1) | 0.3 (0.3) | 0.0001 | |
Notes: Average values of each group are shown. Standard deviations are shown in parenthesis. Differences were tested by Mann–Whitney’s U-test. Specific antigens coated on the fluorescence beads are described in Supplementary Table S1.
Abbreviations: HLA, human leukocyte antigen; RA, rheumatoid arthritis; ILD, interstitial lung disease; ILD(+)RA, RA with ILD; ILD(–)RA, RA without ILD; NC, negative control; Ab: antibody.