Table 1.
Demographic and treatment characteristics of adult survivors of childhood cancer
| Eligible (N=3,029) | Non-participants (N=1,209) | Participants (N=1,820) | Anthracycline Alone (N=1,050) | Chest-directed RT Alone (N=306) | Anthracycline + Chest-directed RT (N=464) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | %* | N | %* | N | %* | N | %* | N | %* | N | %* | |
| Race/Ethnicity | ||||||||||||
| Non-Hispanic White | 2517 | 83.8 | 965 | 81.2 | 1552 | 85.5 | 905 | 86.4 | 260 | 85.0 | 387 | 83.8 |
| Non-Hispanic Black | 415 | 13.8 | 193 | 16.2 | 222 | 12.2 | 116 | 11.1 | 40 | 13.1 | 66 | 14.3 |
| Non-Hispanic Other | 41 | 1.4 | 18 | 1.5 | 23 | 1.3 | 12 | 1.2 | 6 | 2.0 | 5 | 1.1 |
| Hispanic | 31 | 1.0 | 13 | 1.1 | 18 | 1.0 | 14 | 1.3 | 0 | 0.0 | 4 | 0.9 |
| Sex | ||||||||||||
| Male | 1684 | 55.6 | 738 | 61.0 | 946 | 52.0 | 548 | 52.2 | 164 | 53.6 | 234 | 50.4 |
| Female | 1345 | 44.4 | 471 | 39.0 | 874 | 48.0 | 502 | 47.8 | 142 | 46.4 | 230 | 49.6 |
| Age at Diagnosis (years) | ||||||||||||
| 0-4 | 1023 | 33.8 | 404 | 33.4 | 619 | 34.0 | 416 | 39.6 | 69 | 22.6 | 134 | 28.9 |
| 5-9 | 718 | 23.7 | 296 | 24.5 | 422 | 23.2 | 246 | 23.4 | 79 | 25.8 | 97 | 20.9 |
| 10-14 | 731 | 24.1 | 286 | 23.7 | 445 | 24.5 | 242 | 23.1 | 95 | 31.1 | 108 | 23.3 |
| 15-19 | 530 | 17.5 | 210 | 17.4 | 320 | 17.6 | 138 | 13.1 | 61 | 19.9 | 121 | 26.1 |
| >19 | 27 | 0.9 | 13 | 1.1 | 14 | 0.8 | 8 | 0.8 | 2 | 0.7 | 4 | 0.9 |
| Time Since Diagnosis (years) | ||||||||||||
| 10-20 | 1027 | 34.1 | 366 | 30.3 | 661 | 36.3 | 392 | 37.5 | 80 | 26.3 | 189 | 41.3 |
| 21-30 | 1228 | 40.7 | 498 | 41.2 | 730 | 40.1 | 468 | 44.8 | 87 | 28.6 | 175 | 38.2 |
| 31-40 | 643 | 21.3 | 280 | 23.2 | 363 | 19.9 | 179 | 17.1 | 101 | 33.2 | 83 | 18.1 |
| 41-50 | 118 | 3.9 | 65 | 5.4 | 53 | 2.9 | 6 | 0.6 | 36 | 11.8 | 11 | 2.4 |
| Current Age (years) | ||||||||||||
| 18-20 | 139 | 4.6 | 51 | 4.2 | 88 | 4.8 | 69 | 6.6 | 3 | 1.0 | 16 | 3.5 |
| 21-30 | 1193 | 39.6 | 430 | 35.6 | 763 | 41.9 | 506 | 48.4 | 88 | 29.0 | 169 | 36.9 |
| 31-40 | 1112 | 36.9 | 462 | 38.2 | 650 | 35.7 | 356 | 34.1 | 84 | 27.6 | 210 | 45.9 |
| 41-50 | 484 | 16.1 | 217 | 18.0 | 267 | 14.7 | 107 | 10.2 | 103 | 33.9 | 57 | 12.5 |
| >50 | 88 | 2.9 | 49 | 4.1 | 39 | 2.1 | 7 | 0.7 | 26 | 8.6 | 6 | 1.3 |
| Primary Cancer Diagnosis | ||||||||||||
| Leukemia | 1246 | 41.1 | 479 | 39.6 | 767 | 42.1 | 601 | 57.2 | 54 | 17.7 | 112 | 24.1 |
| Acute lymphoblastic leukemia | 1053 | 34.8 | 384 | 31.8 | 669 | 36.8 | 550 | 52.4 | 31 | 10.1 | 88 | 19.0 |
| Acute myeloid leukemia | 146 | 4.8 | 72 | 6 | 74 | 4.1 | 51 | 4.9 | 1 | 0.3 | 22 | 4.7 |
| Other leukemia | 47 | 1.6 | 23 | 1.9 | 24 | 1.3 | 0 | 0.0 | 22 | 7.2 | 2 | 0.4 |
| Lymphoma | 799 | 26.4 | 332 | 27.5 | 467 | 25.7 | 136 | 13.0 | 121 | 39.5 | 210 | 45.3 |
| Non-Hodgkin Lymphoma | 307 | 10.1 | 151 | 12.5 | 156 | 8.6 | 120 | 11.4 | 11 | 3.6 | 25 | 5.4 |
| Hodgkin Lymphoma | 492 | 16.2 | 181 | 15 | 311 | 17.1 | 16 | 1.5 | 110 | 36.0 | 185 | 39.9 |
| CNS tumor | 140 | 4.6 | 62 | 5.1 | 78 | 4.3 | 2 | 0.2 | 76 | 24.8 | 0 | 0.0 |
| Bone tumor | 261 | 8.6 | 88 | 7.3 | 173 | 9.5 | 150 | 14.3 | 0 | 0.0 | 23 | 5.0 |
| Ewing sarcoma | 119 | 3.9 | 38 | 3.1 | 81 | 4.5 | 60 | 5.7 | 0 | 0.0 | 21 | 4.5 |
| Osteosarcoma | 142 | 4.7 | 50 | 4.1 | 92 | 5.1 | 90 | 8.6 | 0 | 0.0 | 2 | 0.4 |
| Other tumors | 23 | 0.8 | 13 | 1.1 | 10 | 0.5 | 0 | 0.0 | 10 | 3.3 | 0 | 0.0 |
| Germ cell tumor | 20 | 0.7 | 11 | 0.9 | 9 | 0.5 | 0 | 0.0 | 9 | 2.9 | 0 | 0.0 |
| Melanoma | 3 | 0.1 | 2 | 0.2 | 1 | 0.1 | 0 | 0.0 | 1 | 0.3 | 0 | 0.0 |
| Soft Tissue Sarcoma | 143 | 4.7 | 59 | 4.9 | 84 | 4.6 | 60 | 5.7 | 5 | 1.6 | 19 | 4.1 |
| Rhabdomyosarcoma | 97 | 3.2 | 43 | 3.6 | 54 | 3 | 42 | 4.0 | 3 | 1.0 | 9 | 1.9 |
| Non-Rhabdo Sarcoma | 46 | 1.5 | 16 | 1.3 | 30 | 1.6 | 18 | 1.7 | 2 | 0.7 | 10 | 2.2 |
| Other Malignancies | 417 | 13.8 | 176 | 14.6 | 241 | 13.2 | 101 | 9.6 | 40 | 13.1 | 100 | 21.6 |
| Neuroblastoma | 142 | 4.7 | 57 | 4.7 | 85 | 4.7 | 60 | 5.7 | 13 | 4.3 | 12 | 2.6 |
| Retinoblastoma | 16 | 0.5 | 11 | 0.9 | 5 | 0.3 | 5 | 0.5 | 0 | 0.0 | 0 | 0.0 |
| Wilms tumor | 230 | 7.6 | 97 | 8 | 133 | 7.3 | 26 | 2.5 | 20 | 6.5 | 87 | 18.8 |
| Carcinoma | 6 | 0.2 | 3 | 0.2 | 3 | 0.2 | 1 | 0.1 | 2 | 0.7 | 0 | 0.0 |
| Other | 23 | 0.8 | 8 | 0.7 | 15 | 0.8 | 9 | 0.9 | 5 | 1.6 | 1 | 0.2 |
| Anthracycline Cumulative Dose (mg/m2) | ||||||||||||
| 0 | 510 | 16.9 | 204 | 17.1 | 306 | 16.9 | 0 | 0.0 | 306 | 100.0 | 0 | 0.0 |
| 1-100 | 784 | 26.0 | 296 | 24.6 | 488 | 26.9 | 419 | 40.0 | 0 | 0.0 | 69 | 15.0 |
| 101-200 | 882 | 29.2 | 364 | 30.3 | 518 | 28.6 | 292 | 27.9 | 0 | 0.0 | 226 | 49.0 |
| 201-300 | 336 | 11.1 | 141 | 11.7 | 195 | 10.8 | 105 | 10.0 | 0 | 0.0 | 90 | 19.5 |
| 301-400 | 332 | 11.0 | 107 | 8.9 | 225 | 12.4 | 163 | 15.6 | 0 | 0.0 | 62 | 13.5 |
| 401-500 | 100 | 3.3 | 41 | 3.4 | 59 | 3.3 | 51 | 4.9 | 0 | 0.0 | 8 | 1.7 |
| 501-600 | 23 | 0.8 | 5 | 0.4 | 18 | 1.0 | 13 | 1.2 | 0 | 0.0 | 5 | 1.1 |
| >600 | 48 | 1.6 | 43 | 3.6 | 5 | 0.3 | 4 | 0.4 | 0 | 0.0 | 1 | 0.2 |
| Chest-directed RT | ||||||||||||
| 0 Gy | 1765 | 60.5 | 715 | 62.1 | 1050 | 59.4 | 1050 | 100.0 | 0 | 0.0 | 0 | 0.0 |
| 1-19.9Gy | 653 | 22.4 | 250 | 21.7 | 403 | 22.8 | 0 | 0.0 | 131 | 45.0 | 272 | 63.7 |
| 20-29.9Gy | 330 | 11.3 | 121 | 10.5 | 209 | 11.8 | 0 | 0.0 | 72 | 24.7 | 137 | 32.1 |
| ≥30Gy | 172 | 5.9 | 66 | 5.7 | 106 | 6.0 | 0 | 0.0 | 88 | 30.2 | 18 | 4.2 |
| Metabolic Syndrome | ||||||||||||
| Yes | -- | -- | -- | -- | 509 | 28.6 | 280 | 27.2 | 99 | 33.5 | 130 | 28.8 |
| No | -- | -- | -- | -- | 1269 | 71.4 | 750 | 72.8 | 197 | 66.6 | 322 | 71.2 |
| Components of Metabolic Syndrome | ||||||||||||
| Abdominal Obesity | ||||||||||||
| Yes | -- | -- | -- | -- | 538 | 30.4 | 355 | 34.5 | 69 | 23.7 | 114 | 25.4 |
| No | -- | -- | -- | -- | 1232 | 69.6 | 675 | 65.5 | 222 | 76.3 | 335 | 74.6 |
| Elevated Triglycerides | ||||||||||||
| Yes | -- | -- | -- | -- | 470 | 26.0 | 234 | 22.4 | 98 | 32.2 | 138 | 30.0 |
| No | -- | -- | -- | -- | 1338 | 74.0 | 810 | 77.6 | 206 | 67.8 | 322 | 70.0 |
| Low HDL Cholesterol | ||||||||||||
| Yes | -- | -- | -- | -- | 665 | 36.8 | 379 | 36.3 | 113 | 37.2 | 173 | 37.6 |
| No | -- | -- | -- | -- | 1143 | 63.2 | 665 | 63.7 | 191 | 62.8 | 287 | 62.4 |
| Hypertension | ||||||||||||
| Yes | -- | -- | -- | -- | 816 | 45.2 | 436 | 41.8 | 160 | 53.2 | 220 | 47.8 |
| No | -- | -- | -- | -- | 989 | 54.8 | 608 | 58.2 | 141 | 46.8 | 240 | 52.2 |
| Fasting Glucose ≥100 mg/dl | ||||||||||||
| Yes | -- | -- | -- | -- | 577 | 31.9 | 295 | 28.2 | 125 | 41.1 | 157 | 34.1 |
| No | -- | -- | -- | -- | 1233 | 68.1 | 750 | 71.8 | 179 | 58.9 | 304 | 65.9 |
| Previously Diagnosed with Cardiomyopathy | -- | -- | -- | -- | 47 | 2.6 | 19 | 1.8 | 10 | 3.3 | 18 | 3.9 |
| Previously Diagnosed with Cardiomyopathy and on Medications at the Time of Evaluation | -- | -- | -- | -- | 23 | 1.3 | 7 | 0.7 | 6 | 2.0 | 10 | 2.2 |
*
Percentages provided for total number of participants for whom data were available for a given characteristic.