Table 2.
Multivariable associations between treatment characteristics and systolic and diastolic dysfunction in adult survivors of childhood cancer
| 3D Echo <50% | Abnormal global Longitudinal Strain | Abnormal Global Circumferential strain | Diastolic Grade 1-3 | Abnormal Septal eā | Abnormal Left Atrial Volume | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RR | 95% CI | RR | 95% CI | RR | 95% CI | RR | 95% CI | RR | 95% CI | RR | 95% CI | |
| Race/Ethnicity | ||||||||||||
| Other | 1.53 | 0.93 - 2.52 | 1.22 | 1.03 - 1.46 | 0.84 | 0.64 - 1.09 | 1.24 | 0.86 - 1.78 | 1.32 | 0.89 - 1.96 | 2.03 | 1.41 - 2.93 |
| Non-Hispanic White | 1 | 1 | 1 | 1 | 1 | |||||||
| Sex | ||||||||||||
| Female | 0.54 | 0.36 - 0.83 | 1.55 | 1.34 - 1.79 | 1.01 | 0.84 - 1.21 | 1.15 | 0.88 - 1.51 | 0.98 | 0.73 - 1.32 | 0.6 | 0.43 - 0.83 |
| Male | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| Age at Diagnosis (years) | ||||||||||||
| 0-4 | 0.66 | 0.35 - 1.27 | 1.02 | 0.82 - 1.27 | 1.24 | 0.92 - 1.67 | 0.85 | 0.56 - 1.29 | 0.91 | 0.58 - 1.44 | 1.26 | 0.79 - 2.01 |
| 5-9 | 0.67 | 0.36 - 1.25 | 0.92 | 0.74 - 1.15 | 1.01 | 0.74 - 1.38 | 0.81 | 0.53 - 1.22 | 0.8 | 0.50 - 1.26 | 1.23 | 0.74 - 2.05 |
| 10-14 | 1.02 | 0.59 - 1.76 | 1.02 | 0.83 - 1.24 | 1.11 | 0.84 - 1.48 | 0.87 | 0.61 - 1.23 | 0.77 | 0.50 - 1.17 | 1.18 | 0.74 - 1.86 |
| ā„15 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| Current Age (years) | ||||||||||||
| 31-40 | 1.38 | 0.81 - 2.35 | 1.25 | 1.05 - 1.48 | 0.85 | 0.69 - 1.06 | 2.43 | 1.59 - 3.71 | 1.96 | 1.31 - 2.93 | 2.4 | 1.67 - 3.45 |
| >40 | 0.98 | 0.52 - 1.84 | 1.49 | 1.20 - 1.85 | 0.98 | 0.73 - 1.33 | 4.74 | 2.90 - 7.75 | 1.52 | 0.90 - 2.54 | 3.59 | 2.25 - 5.73 |
| 18-30 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| Anthracycline Cumulative Dose (mg/m2) | ||||||||||||
| 1-100 | 1.74 | 0.66 - 4.61 | 1.38 | 1.05 - 1.82 | 0.99 | 0.66 - 1.48 | 0.75 | 0.43 - 1.30 | 0.62 | 0.29 - 1.32 | 2.07 | 0.95 - 4.51 |
| 101-200 | 2.80 | 1.24 - 6.31 | 1.16 | 0.89 - 1.50 | 1.24 | 0.86 - 1.79 | 0.80 | 0.51 - 1.25 | 1.13 | 0.65 - 1.97 | 1.82 | 0.85 - 3.91 |
| 201-300 | 3.80 | 1.59 - 9.10 | 1.06 | 0.78 - 1.45 | 1.36 | 0.90 - 2.04 | 0.76 | 0.42 - 1.37 | 1.77 | 0.99 - 3.15 | 1.34 | 0.55 - 3.25 |
| 301-400 | 4.76 | 2.16 - 10.50 | 1.72 | 1.31 - 2.26 | 1.61 | 1.08 - 2.40 | 1.00 | 0.59 - 1.69 | 1.53 | 0.84 - 2.81 | 1.72 | 0.73 - 4.05 |
| >400 | 7.71 | 3.04 - 19.57 | 1.73 | 1.19 - 2.50 | 1.34 | 0.78 - 2.31 | 1.33 | 0.72 - 2.45 | 2.05 | 0.99 - 4.24 | 0.95 | 0.30 - 2.99 |
| None | 1 | 1 | 1 | 1 | 1 | 1 | ||||||
| Chest RT Cumulative Dose (Gy) | ||||||||||||
| 1-19.9 | 1.24 | 0.70 - 2.22 | 1.38 | 1.14 - 1.66 | 0.86 | 0.66 - 1.11 | 1.47 | 0.99 - 2.20 | 1.09 | 0.69 - 1.72 | 0.47 | 0.29 - 0.78 |
| 20-29.9 | 1.86 | 1.00 - 3.45 | 1.65 | 1.31 - 2.08 | 1.14 | 0.83 - 1.57 | 2.03 | 1.30 - 3.17 | 2.01 | 1.27 - 3.21 | 1.1 | 0.65 - 1.87 |
| ā„30 | 7.99 | 3.88 - 16.48 | 2.39 | 1.79 - 3.18 | 1.64 | 1.05 - 2.56 | 2.44 | 1.44 - 4.14 | 4.03 | 2.22 - 7.32 | 0.63 | 0.21 - 1.89 |
| None | 1 | 1 | 1 | 1 | 1 | 1 | ||||||