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Proposed immune-based model for detection of active and latent TB. Taking into account the analysis of activated CD4+ T cells, it is possible to differentiate Mtb-infected subjects (>0.45%) by uninfected subjects (<0.45%). With the analysis of multifunctional CD4+ T cells, simultaneously producing all 3 cytokines, infected individuals may be classified as active TB subjects (<0.182%) or as LTBI subjects (>0.182%).
