Table 3.
Ventricular function at the time of cardiotoxicity by chemotherapy agent received.
| (+) Anthracycline n = 22 |
(−) Anthracycline n = 8 |
|
|---|---|---|
| Time to toxicity in months* | 5 (5) | 7.5 (5.7) |
| Left ventricle | ||
| Baseline EF by MUGA (%) |
62 ± 6 | 60 ± 3 |
| Cardiotoxicity EF by MUGA (%) |
48 ± 4 | 47 ± 4 |
| Cardiotoxicity EF by ECHO (%) |
46 ± 6 | 44 ± 5 |
| Cardiotoxicity GLS |
−15.5 ± 2.5 | −15.7 ± 2.5 |
| Right ventricle | ||
| Baseline EF by MUGA (%) |
46 ± 4 | 43 ± 3 |
| Cardiotoxicity EF by MUGA (%) |
44 ± 6 | 40 ± 5 |
| Cardiotoxicity FAC by ECHO (%) |
42 ± 8 | 43 ± 5 |
| Cardiotoxicity RVFWLS |
−24.1 ± 3.9 | −27.4 ± 4.6 |
| Cardiotoxicity RVGLS |
−20.4 ± 2.8 | −22.8 ± 3.2 |
*Median (IQR) onset of cardiotoxicity which occurred after initiation of TZM therapy in 21 patients; in 1 patient toxicity occurred after 3 months from the start of chemotherapy. Abbreviations as per Table 2.