Fig 6. Parameter study.

%changes in total ammonia flows resulting from multiplying each baseline parameter by 5: A) changes at the papillary tip of long loops, B) changes at the tip of short loops (outer-inner medullary junction), C) changes in total ammonia secretion into the collecting ducts, D) changes in urinary excretion. Parameters associated with ammonia recycling in the loops of Henle (especially of short nephrons, see B) are associated with the largest increase in urinary ammonia flow (D). The figure only shows the parameters that affect urinary ammonia excretion by at least 10%. Vmax^AL: maximum rate of active transport of ${\mathrm{\text{NH}}}_4^{+}$ in thick ascending limbs; ${\mathrm{\text{P}}}_{N{H}_3}^{DLOS}$ / ${\mathrm{\text{P}}}_{N{H}_3}^{ALIS}$ / ${\mathrm{\text{P}}}_{N{H}_3}^{CSIS}$ NH₃ permeability of outer stripe descending limbs/ inner stripe ascending limbs/ inner stripe collecting ducts; ${\mathrm{\text{P}}}_{N{H}_4^{+}}^{DVRIS}$ ${\mathrm{\text{NH}}}_4^{+}$ permeability in descending vasa recta of the inner stripe.