Table 3. Parameter analyses based on three alternative baseline scenarios.

Scenarios
DL partly impermeable		No external osmoles		No production		Cortical Amm
${\mathrm{\text{Vmax}}}_{{\mathrm{\text{NH}}}_4^{+}}^{\mathrm{\text{AL}}}$	++++	${\mathrm{\text{Vmax}}}_{{\mathrm{\text{NH}}}_4^{+}}^{\mathrm{\text{AL}}}$	++++	${\mathrm{\text{Vmax}}}_{{\mathrm{\text{NH}}}_4^{+}}^{\mathrm{\text{AL}}}$	++++	${\mathrm{\text{P}}}_{{\mathrm{\text{NH}}}_3}^{\mathrm{\text{DL OS}}}$	++++
${\mathrm{\text{P}}}_{{\mathrm{\text{NH}}}_3}^{\mathrm{\text{DL OS}}}$	++++	${\mathrm{\text{P}}}_{{\mathrm{\text{NH}}}_3}^{\mathrm{\text{DL OS}}}$	++++	${\mathrm{\text{P}}}_{{\mathrm{\text{NH}}}_3}^{\mathrm{\text{DL OS}}}$	++++	${\mathrm{\text{Vmax}}}_{{\mathrm{\text{NH}}}_4^{+}}^{\mathrm{\text{AL}}}$	++++
${\mathrm{\text{P}}}_{{\mathrm{\text{NH}}}_4^{+}}^{\mathrm{\text{AL IS}}}$	++	${\mathrm{\text{P}}}_{{\mathrm{\text{NH}}}_4^{+}}^{\mathrm{\text{AL IS}}}$	++	${\mathrm{\text{P}}}_{{\mathrm{\text{NH}}}_4^{+}}^{\mathrm{\text{DVR OS}}}$	++	${\mathrm{\text{P}}}_{{\mathrm{\text{NH}}}_4^{+}}^{\mathrm{\text{DVR OS}}}$	+++
${\mathrm{\text{P}}}_{{\mathrm{\text{NH}}}_4^{+}}^{\mathrm{\text{DVR OS}}}$	++	${\mathrm{\text{P}}}_{{\mathrm{\text{NH}}}_4^{+}}^{\mathrm{\text{DVR OS}}}$	++	${\mathrm{\text{P}}}_{{\mathrm{\text{NH}}}_4^{+}}^{\mathrm{\text{AL IS}}}$	++	${\mathrm{\text{P}}}_{{\mathrm{\text{NH}}}_4^{+}}^{\mathrm{\text{AL IS}}}$	+++
		${\mathrm{\text{P}}}_{{\mathrm{\text{NH}}}_3}^{\mathrm{\text{CD IS}}}$	+	${\mathrm{\text{P}}}_{{\mathrm{\text{NH}}}_3}^{\mathrm{\text{CD IS}}}$	+	${\mathrm{\text{P}}}_{{\mathrm{\text{NH}}}_3}^{\mathrm{\text{CD IS}}}$	+
				${\mathrm{\text{P}}}_{{\mathrm{\text{NH}}}_3}^{\mathrm{\text{DL IS}}}$	+
				${\mathrm{\text{P}}}_{{\mathrm{\text{NH}}}_3}^{\mathrm{\text{AL IS}}}$	-
				${\mathrm{\text{P}}}_{{\mathrm{\text{NH}}}_4^{+}}^{\mathrm{\text{DL OS}}}$	-

‘DL partly impermeable’: in this scenario, some sub-segments of the descending limbs are assumed to be water impermeable (the outer-stripe of superficial nephrons, the inner medullary segment of juxtamedullary nephrons whose loop of Henle bends within the first millimeter of the inner medulla, and the last 60% of inner medullary segment of juxtamedullary nephron which go deeper in the inner medulla). ‘no external osmoles’: in this scenario, the external osmoles concentrations in the inner medulla are set to 0. ‘No production’: ammonia production is set to 0. ‘Cortical Amm’: in this scenario, ammonia delivered to the collecting ducts is proportional to ammonia flow at the exit of the ascending limbs. The number of ‘+’ in ‘-’ corresponds to the percentage change of the rate of ammonia excretion from the corresponding baseline scenario: ‘-’ for -20% to -10%; ‘+’ for 10% to 20%; ‘++’ for 20% to 30%; ‘+++’ for 30% to 40%; ‘++++’ for > 40%.