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. 2015 Aug 17;10(8):e0134243. doi: 10.1371/journal.pone.0134243

Fig 2. Higher matrix stiffness activates GSK3β/β-catenin signaling pathway mediated by integrin-β1 to modulate OPN expression.

Fig 2

(A) Levels of P-GSK3β and β-catenin were attenuated in HCC cells infected with LV-INTGB1-RNAi on high stiffness substrate. Nuclear expression of β-catenin and TCF dropped sharply, and the expression of OPN also decreased significantly. (B) OPN expression Huh7 and Hep3B cells infected with LV-ITGB1-RNAi on high stiffness substrate. In each case, error bars represent SD, *p < 0.05, **p < 0.01, ***p<0.0001.