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. 2015 Aug 17;10(8):e0134243. doi: 10.1371/journal.pone.0134243

Fig 4. Expressions of COL1, LOX, and OPN in HCC tissue with different matrix stiffness backgrounds.

Fig 4

(A) Representative HCC tumor samples show the expression levels of COL1, LOX and OPN. HCC tissue in Groups 1, 2, and 3 are defined as normal liver stiffness background tissue, medium stiffness and high stiffness liver background tissue, respectively[22]. (B) Graphs showing the average IOD value of COL1, LOX and OPN expression in the three groups analyzed by image pro-plus 6.0 software. In each case, error bars represent SD, *p < 0.05, **p < 0.01, ***p<0.0001. (C) Multiple linear regression indicates that the levels of OPN are positively correlated with the expression levels of LOX and COL1.