TABLE 1.
Patient characteristics and treatment of recurrences after BCS in two cohorts of women with DCIS
| NCCN (N = 88) |
CRN (N = 182) |
|
|---|---|---|
| Demographics | ||
| Patient age [years; mean (SD)] | 53.6 (11.3) | 55.9 (11.6) |
| BMI [mean (SD)] | 27.2 (6.4) | 26.3 (4.8) |
| Race | ||
| Caucasian | 71 (80.7 %) | 131 (72.0) |
| Black | 7 (8.0 %) | 17 (9.3 %) |
| Other | 10 (11.4 %) | 34 (18.7 %) |
| Index DCIS | ||
| Received radiation | 61 (69.3 %) | 60 (33.0 %) |
| Time to recurrence [mean no. of months (SD)] | 39.7 (26.2) | 45.4 (32.0) |
| In-breast recurrence | ||
| DCIS only | 52 (59.1 %) | 97 (53.3 %) |
| Invasive component | 36 (40.9 %) | 85 (46.7 %) |
| Surgical treatment | ||
| BCS | 14 (15.9 %) | 71 (39.0 %) |
| Mastectomy alone | 35 (39.8 %) | 79 (43.4 %) |
| Mastectomy + reconstruction | 39 (44.3 %) | 32 (17.6 %) |
| Timing of reconstruction | ||
| Immediate | 36 (92.3 %) | 23 (71.9 %) |
| Delayed | 3 (7.7 %) | 9 (28.1 %) |
| Type of reconstruction | ||
| Autologous tissue | 26 (66.7 %) | 5 (15.6 %) |
| Implant/expander | 13 (33.3 %) | 27 (84.4 %) |
| Received radiation | ||
| BCS | 7 (70.0 %) | 19 (73.1 %) |
| Mastectomy only | 3 (30.0 %) | 6 (23.1 %) |
| Mastectomy + reconstruction | 0 | 1 (3.8 %) |
| Received chemotherapy | 11 (12.5 %) | 20 (11.0 %) |
| Surgical complicationsb | 10 (11.3 %) | 54 (29.7 %) |
Recurrence including both DCIS and invasive cancer
The first cohort includes those patients who were diagnosed with an ipsilateral recurrence of DCIS or invasive cancer following an index case of DCIS in NCCN between 1997 and 2008. The other includes patients with an ipsilateral recurrence following treatment for index DCIS at a CRN institution between 1990 and 2001
BCS breast-conserving surgery, DCIS ductal carcinoma in situ, NCCN National Comprehensive Cancer Network, CRN Cancer Research Network, BMI body mass index
NCCN data collection was limited to major complications that were documented in medical records, while the CRN data includes both major and minor complications