TABLE 2.
Relationship of radiation treatment of index DCIS and treatment of ipsilateral recurrence
| NCCN | CRN | |||||
|---|---|---|---|---|---|---|
| BCS + XRT (N = 61) |
BCS alone (N = 27) |
p value | BCS + XRT (N = 60) |
BCS alone (N = 122) |
p value | |
| Demographics | ||||||
| Age [years; mean (SD)] | 53.5 (10.5) | 54.1 (13.1) | 0.81 | 55.1 (8.9) | 56.3 (12.7) | 0.54 |
| BMI [mean (SD)] | 27.8 (6.2) | 26.1 (6.9) | 0.27 | 26.4 (4.7) | 26.2 (4.9) | 0.82 |
| Race | ||||||
| Caucasian | 48 (78.7 %) | 23 (85.2 %) | 0.27 | 43 (71.7 %) | 88 (72.1 %) | 0.91 |
| Black | 5 (8.2 %) | 2 (7.4 %) | 5 (8.3 %) | 12 (9.8 %) | ||
| Other | 8 (13.1 %) | 2 (7.4 %) | 12 (20.0 %) | 22 (18.0 %) | ||
| In-breast recurrence | ||||||
| Time from initial diagnosis to recurrence | 41.1 (27.4) | 36.9 (23.5) | 0.49 | 48.4 (31.7) | 43.9 (32.1) | 0.37 |
| DCIS only | 39 (63.9 %) | 13 (48.2 %) | 0.24 | 34 (56.7 %) | 63 (51.6 %) | 0.52 |
| Invasive component | 22 (36.1 %) | 14 (51.9 %) | 26 (43.3 %) | 59 (48.4 %) | ||
| Surgical treatment | ||||||
| Repeat BCS | 4 (6.6 %) | 10 (37.0 %) | 0.0009 | 12 (20.0 %) | 59 (48.4 %) | 0.0003 |
| Mastectomy alone | 25 (41.0 %) | 10 (37.0 %) | 38 (63.3 %) | 41 (33.6 %) | ||
| Mastectomy + reconstruction | 32 (52.5 %) | 7 (25.9 %) | 10 (16.7 %) | 22 (18.0 %) | ||
| Timing of reconstruct | ||||||
| Immediate | 30 (93.8 %) | 6 (85.7 %) | 0.46 | 9 (90.0 %) | 14 (63.6 %) | 0.21 |
| Delayed | 2 (6.3 %) | 1 (14.3 %) | 1 (10 %) | 8 (36.4 %) | ||
| Type of reconstruction | ||||||
| Autologous tissue | 25 (78.1 %) | 1 (14.3 %) | 0.003 | 2 (20.0 %) | 3 (13.6 %) | 0.21 |
| Implant/expander | 7 (21.9 %) | 6 (85.7 %) | 8 (80.0 %) | 19 (86.4 %) | ||
| XRT for recurrence | ||||||
| BCS | 0 (0.0 %) | 7 (70.0 %) | a | 1 (8.3 %) | 18 (30.5 %) | a |
| Mastectomy only | 0 (0.0 %) | 3 (30.0 %) | 0 (0 %) | 6 (14.6 %) | ||
| Mastectomy + reconstruction | 0 (0.0 %) | 0 (0.0 %) | 0 (0 %) | 1 (4.5 %) | ||
| Received chemotherapy | 5 (8.2 %) | 6 (22.2 %) | 0.085 | 6 (10.0 %) | 14 (11.5 %) | 0.76 |
| Surgical complicationb | 9 (14.8 %) | 1 (3.7 %) | 0.17 | 24 (40.0 %) | 30 (24.6 %) | 0.09 |
Recurrence including both DCIS and invasive cancer
DCIS ductal carcinoma in situ, NCCN National Comprehensive Cancer Network, CRN Cancer Research Network, BCS breast-conserving surgery, XRT radiation therapy, BMI body mass index
a
p-Value not calculated due to cells containing a value of zero
b
Includes all complications in the CRN cohort, and only major complications that were evident in medical records in the NCCN cohort