Table 1.
| a: Characteristics of Parkinson’s disease (IPDGC) and primary Alzheimer’s disease (ADGC) genome-wide association studies evaluated in this manuscript. | ||||
|---|---|---|---|---|
| IPDGC | ADGC | |||
| Cases | Controls | Cases | Controls | |
| N | 5333 | 12019 | 11840 | 10931 |
| Age at assessment (mean) | 57.6 | 67.8 | 80.6 | 76.7 |
| % Women | 41 | 48.7 | 61 | 58.5 |
| % APOE ε4 carriers | N/A | N/A | 51.6 | 26.7 |
| b: Demographic, clinical, and imaging data for all ADNI participants evaluated in this study. AD = Alzheimer’s disease, MCI = mild cognitive impairment, HC = cognitively normal older adults, MMSE = Mini-mental status exam, CDR-SB = Clinical Dementia Rating-Sum of Boxes score | |||
|---|---|---|---|
| HC (n = 174) |
MCI (n = 311) |
AD (n = 135 ) |
|
| Age, Mean (SD) | 76.3 (5.1) | 75.0 (7.3) | 75.4 (7.7) |
| Female, % | 48 | 36 | 48 |
| Education Years, Mean (SD) | 16.1 (2.7) | 15.7 (2.9) | 14.9 (2.9) |
| CDR-SB, Mean (SE) | 0.03 (0.11) | 1.6 (0.9) | 4.2 (1.5) |
| APOE ε4 carriers (%) | 25 | 57 | 69 |
| Entorhinal cortex APC, Mean (SD) | −0.57 (2.5) | −2.10 (1.6) | −2.92 (1.7) |
| Hippocampus APC, Mean (SD) | −0.90 (1.1) | −2.19 (1.7) | −3.45 (1.9) |