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Homology model of TM284var1 DBL4ζ.
The TM284var1 sequence starting from Glu1481 to Thr1952 was used to generate a model of DBL4ζ based on the structure of DBL6ϵ of 3D7var2CSA as described previously [16]. Amino acids 1595–1814, the minimal IgM binding region, are shown in orange. Negatively charged amino acids postulated to bind IgM are shown in red (Glu1663, Glu1665 and Glu1779, and positively charged residues in blue (Arg1764 and Lys1782).
